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Rare coding SNP in DZIP1 gene associated with late-onset sporadic Parkinson's disease

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arxiv 1109.0029 v2 pith:VWDZAFS2 submitted 2011-08-31 q-bio.GN

Rare coding SNP in DZIP1 gene associated with late-onset sporadic Parkinson's disease

classification q-bio.GN
keywords diseaseparkinsonassociationdzip1codinggenegenome-widelate-onset
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We present the first application of the hypothesis-rich mathematical theory to genome-wide association data. The Hamza et al. late-onset sporadic Parkinson's disease genome-wide association study dataset was analyzed. We found a rare, coding, non-synonymous SNP variant in the gene DZIP1 that confers increased susceptibility to Parkinson's disease. The association of DZIP1 with Parkinson's disease is consistent with a Parkinson's disease stem-cell ageing theory.

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