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The interplay between diversity and noise in an excitable cell network model

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arxiv 2203.12506 v1 pith:Y6QLFOS3 submitted 2022-03-23 physics.bio-ph

The interplay between diversity and noise in an excitable cell network model

classification physics.bio-ph
keywords networkdiversitynoisecellelementsexcitableinterplaymodel
verification ladder T0 review T1 audit T2 compute T3 formal T4 reserved
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We study the interplay between diversity and noise in a 3D network of FitzHugh-Nagumo elements, with topology and dimensions chosen to model a pancreatic beta-cell cluster, as an example of an excitable cell network. Our results show that diversity and noise are not equivalent sources of disorder but have different effects on network dynamics. Their synchronization mechanisms may act independently of one another or synergistically, depending on the mean value of the diversity distribution compared to the intrinsic oscillatory range of the network elements.

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